IL-5
IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant murine IL-5 is a 26.2 kDa disulfide-linked homodimeric protein containing two 113 amino acid chains.
Product Specifications
Synonyms
Il5; Il-5; B-cell growth factor II; Short name=BCGF-II; Cytotoxic T-lymphocyte inducer; Eosinophil differentiation factor; T-cell replacing factor
NCBI Gene ID
16191
UniProt
P04401
Accession Number
NP_034688.1
Accession Number mRNA
NM_010558.1
Chromosomal Location
11 A5/B1; 11 29.2 cM
Reactivity
Mouse
Cross Reactivity
Human, Mouse
Sequence
MEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Length
113
Form
Lyophilized
Molecular Weight
26.2 kDa
Host or Source
E. coli
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