IL-37 (IL-1F7)
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-37 (IL-1F7), which acts as a modulator of the immune response. Reduction of IL-37 synthesis in PBMCs leads to increased production of proinflammatory cytokines including IL-1 alpha, IL-1 beta, IL-6 and TNF- alpha. The role of IL-37 as an inhibitor of the innate inflammatory response is also corroborated by the observation that it is highly expressed in synovial tissue from patients with rheumatoid arthritis. Full length IL-37 resides primarily in the cytoplasm, but after activation through cleavage by CASP1, it can translocate to the nucleus where it exerts its activity by direct interaction with SMAD3. Recombinant Human IL-37 is a 19.4 kDa protein consisting of 174 amino acids, corresponding to the mature activated form of IL-37.
Product Specifications
Synonyms
Interleukin-37, IL-1F7, IL-1ζ (zeta), IL-1H4
NCBI Gene ID
27178
UniProt
Q9NZH6
Accession Number
NP_055254.2.
Accession Number mRNA
NM_014439.3.
Reactivity
Human
Cross Reactivity
Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Measured by its ability to bind Interleukin-18 Binding Protein isoform a (IL-18 BPa) in functional ELISA.
Length
174
Form
Lyophilized
Molecular Weight
19.4 kDa
Host or Source
E. coli
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