HCC-1
HCC-1 is a CC chemokine that signals through the CCR1 receptor and chemoattracts blood monocytes. It is secreted by various tissues, including skeletal muscle, heart, spleen, liver, bone marrow and plasma. Mature HCC-1 is found in four different forms, which are distinguished by differential N-terminal truncation and contain 74, 72, 71, or 66 amino acid residues. Recombinant Human HCC-1 (CCL14) is a 7.8 kDa protein consisting of 66 amino acids, including the four highly conserved residues present in CC chemokines.
Product Specifications
Synonyms
CCL14; CC-1; CC-3; CKB1; MCIF; NCC2; SY14; HCC-1; HCC-3; NCC-2; SCYL2; SCYA14; HCC-1 (1-74) ; HCC-1/HCC-3
NCBI Gene ID
6358
UniProt
Q16627
Accession Number
NP_116739
Accession Number mRNA
NM_032963
Chromosomal Location
17q11.2
Reactivity
Human
Cross Reactivity
Mouse, Human
Sequence
GPYHPSECCF TYTTYKIPRQ RIMDYYETNS QCSKPGIVFI TKRGHSVCTN PSDKWVQDYI KDMKEN
Assay Protocol
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human monocytes using a concentration range of 5.0-20.0 ng/ml.
Length
66
Form
Lyophilized
Molecular Weight
7.8 kDa
Storage Conditions
Host or Source
E. coli
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