SARS-CoV/SARS-CoV-2 Variant (Delta, Omicron (BA.1/BA.5) ) Spike Trimer Antibody [T3P1E1]
Product Specifications
Background
Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1) . The disease is the cause of the 2019–20 coronavirus outbreak (2) . The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection (3) . The spike protein is the major target for neutralizing antibodies and vaccine development (4) . The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (5) . The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (6) .
NCBI Gene ID
43740568
Swiss Prot
P0DTC2
Accession Number
QHD43419
Host
Llama
Reactivity
Virus
Immunogen
SARS-CoV-2 variant Spike proteins.
Clonality
Recombinant Monoclonal
Clone
T3P1E1
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Infectious Disease, COVID-19
Purification
SARS-CoV/SARS-CoV-2 Variant (Delta, Omicron (BA.1/BA.5) ) Spike Trimer Antibody is affinity chromatography purified via Nickel column. Antibody is supplied as a His-tagged purified protein. It also contains a myc-tag for detection.
Concentration
Batch dependent
Buffer
SARS-CoV/SARS-CoV-2 Variant (Delta, Omicron (BA.1/BA.5) ) Spike Trimer Antibody is supplied in PBS.
Modification
None
Shipping Conditions
Dry Ice
Storage Conditions
SARS-CoV/SARS-CoV-2 Variant (Delta, Omicron (BA.1/BA.5) ) Spike Trimer Antibody should be stored in working aliquots at -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=SD9983
Fragment
SdAb
Symbol
S
NCBI Official Name
Surface glycoprotein
NCBI Organism
SARS-CoV-2
Background Reference 01
Gorbalenya. bioRxiv: 2020.
Background Reference 02
Hui et al. Int J Infect Dis. 2020;91:264-266.
Background Reference 03
Belouzard et al. Viruses. 2012;4 (6) :1011-33.
Background Reference 04
Lee et al. J Virol. 2006;80 (8) :4079-87.
Background Reference 05
Wan et al. J Virol. 2020.
Background Reference 06
Wrapp et al. Science. 2020.
Other Product Names
SARS-CoV/SARS-CoV-2 Variant (Delta, Omicron (BA.1/BA.5) ) Spike Trimer Antibody: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Surface Glycoprotein, Spike protein
Tested Applications
ELISA
Protein ID
1791269090
Physical Properties
Liquid
Available Sizes
Curated Selection
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