CD49d Antibody [PS/2]
Product Specifications
Background
VLA-4 belongs to the beta1-integrin family, which functions both as cell-matrix and cell-cell receptors. As a matrix receptor VLA-4 binds to an alternatively spliced domain of fibronectin, while as a cellular receptor it associates with its counter-receptor ligand VCAM-1. In addition to CD44/Pgp-1, VLA-4 has been shown to be important for lymphopoiesis, and is also believed to be important for extravasation of lymphocytes into sites of inflammation as a second signal in addition to LFA/ICAM-1. CD49d is expressed in low amounts on resting lymphocytes and monocytes, is absent or minimally detectable on stromal cells, whereas virtually all lymphoid and myeloid cells in bone marrow and in long-term culture are positive. Antibody PS/2 also reacts with human VLA-4.
NCBI Gene ID
16401
Swiss Prot
Q00651
Accession Number
Q00651
Host
Rat
Reactivity
Mouse, Human
Immunogen
P815 cells
Clonality
Monoclonal
Clone
[PS/2]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Concentration
0.5 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgG2b
Specificity
CD49d
Applications Notes
CD49d Antibody [PS/2] for use in flow cytometry, immunohistochemistry, immunoprecipitation, blocking, and adhesion assays.
Symbol
Itga4
NCBI Official Name
Integrin alpha 4
NCBI Organism
Mus musculus
Other Product Names
Integrin alpha4, VLA-4alpha, ITGA4, IA4
Tested Applications
ELISA
Physical Properties
Liquid
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
