MAP2K7 (phospho Ser271) Antibody

Product Specifications

Background

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.

NCBI Gene ID

5609

Swiss Prot

O14733

Accession Number

NP_660186.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

MAP2K7 (phospho Ser271) antibody was raised against a peptide sequence around phosphorylation site of Serine271 (V-D-S (p) -K-A) derived from Human MAP2K7.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

60 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of MAP2K7 only when phosphorylated at serine 271.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Symbol

MAP2K7

NCBI Official Name

Mitogen-activated protein kinase kinase 7

NCBI Organism

Homo sapiens

Background Reference 01

Wu Z., Mol. Cell. Biol. 17:7407-7416 (1997) .

Background Reference 02

Lu X., J. Biol. Chem. 272:24751-24754 (1997) .

Background Reference 03

Foltz I.N., J. Biol. Chem. 273:9344-9351 (1998) .

Other Product Names

PRKMK7, JNKK2, MKK7, MAP2K7, MP2K7

Tested Applications

WB, IHC

Protein ID

21735544

Physical Properties

Liquid

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