CD152 Antibody [BNI3]

Product Specifications

Background

The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) . CTLA-4 is expressed on activated CD28+ T cells, and binds the B7 family members B7-1 (CD80) and B7-2 (CD86) . The structure of CTLA-4 is similar to the structure of CD28, but the two molecules seem to have opposite roles on the T lymphocytes. CTLA-4 inhibits the progression of T cell activation, while CD28 stimulates it. This result explains the stimulating role that the immobilization of BNI3 plays on the T lymphocytes proliferation induced by CD28.

NCBI Gene ID

1493

Swiss Prot

P16410

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

BNI3

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C . Do not freeze.

Fragment

Mouse IgG2a, kappa

Specificity

The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) .

Symbol

CTLA4

NCBI Official Name

Cytotoxic T-lymphocyte-associated protein 4

NCBI Organism

Homo sapiens

Background Reference 01

Barclay, A. N., Brown, M. H., Law, S. A. K. A., McKnight, A. J., Tomlinson, M. G., van der Merwe, P. A. (1997) .The leucocyte antigen factsbook. Academic Press.

Background Reference 02

Lindsten, T., Lee, K. P., Harris, E. S., Petryniak, B., Craighead, N., Reynolds, P. J., ... Gray, G. S. (1993) . Characterization of CTLA-4 structure and expression on human T cells.The Journal of Immunology,151 (7), 3489-3499.

Background Reference 03

Kuiper, H. M., Brouwer, M., Linsley, P. S., Van Lier, R. A. (1995) . Activated T cells can induce high levels of CTLA-4 expression on B cells.The Journal of Immunology,155 (4), 1776-1783.