JUN Antibody

Product Specifications

Background

V-jun avian sarcoma virus 17 oncogene homolog; Jun activation domain binding protein. The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. The JUN gene product has also been shown to be structurally and functionally identical to the enhancer binding protein, AP-1; thus AP-1 may be encoded by JUN. The JUN protein interacts directly with specific target DNA sequences to regulate gene expression. JUN has been mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.

NCBI Gene ID

3725

Swiss Prot

P05412

Accession Number

NP_002219.1

Host

Chicken

Reactivity

Human, Mouse, Rat

Immunogen

1-240

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction, Inflammasomes

Purification

Antigen affinity-purified

Concentration

1 mg/mL

Buffer

Phosphate-Buffered Saline. No preservatives added.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

JUN antibody can be stored at 4˚ C for short term (weeks) . Long term storage should be at -20˚ C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

35.7 kDa (calculated)

Applications Notes

Jun antibody can be used for the detection of Jun by Western blot, may also work for IHC and ICC.

Symbol

JUN

NCBI Official Name

Jun proto-oncogene

NCBI Organism

Homo sapiens

Background Reference 01

Eferl, R., Ricci, R., Kenner, L., Zenz, R., David, J. -P., Rath, M., Wagner, E. F. Liver tumor development: c-Jun antagonizes the proapoptotic activity of p53. Cell 112: 181-192, 2003.