CD1E Antibody
Product Specifications
Background
CD1E encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members.
NCBI Gene ID
913
Swiss Prot
P15812
Accession Number
P15812
Host
Rabbit
Reactivity
Human
Immunogen
This CD1E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 184-212 amino acids from the Central region of human CD1E.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Symbol
CD1E
NCBI Official Name
T-cell surface glycoprotein CD1e, membrane-associated
NCBI Organism
Homo sapiens
Background Reference 01
Maitre, B., et al. Biochem. J. 419 (3) :661-668 (2009)
Background Reference 02
Kuijf, M.L., et al. J. Neuroimmunol. 205 (1-2), 110-112 (2008)
Background Reference 03
Maitre, B., et al. Traffic 9 (4) :431-445 (2008)
Other Product Names
T-cell surface glycoprotein CD1e, membrane-associated, hCD1e, R2G1, CD1e, T-cell surface glycoprotein CD1e, soluble, sCD1e, CD1E
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
254763260
Physical Properties
Liquid
Curated Selection
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