CFP Antibody
Product Specifications
Background
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections.
NCBI Gene ID
5199
Swiss Prot
P27918
Accession Number
P27918
Host
Rabbit
Reactivity
Human
Immunogen
This CFP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 197-223 amino acids from the Central region of human CFP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
51 kDa
Fragment
Rabbit Ig
Symbol
CFP
NCBI Official Name
Properdin
NCBI Organism
Homo sapiens
Background Reference 01
Seitsonen, S., et al. Mol. Immunol. 47 (6) :1334-1336 (2010)
Background Reference 02
Chapuis, J., et al. Mol. Psychiatry 14 (11) :1004-1016 (2009)
Background Reference 03
Wolf-Schnurrbusch, U.E., et al. Retina (Philadelphia, Pa.) 29 (7) :966-973 (2009)
Background Reference 04
Keslar, K., et al. Transplantation 86 (9) :1319-1321 (2008)
Other Product Names
Properdin, Complement factor P, CFP, PFC
Tested Applications
WB, Flow
Protein ID
464473
Physical Properties
Liquid
Curated Selection
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