DNAJC2 Antibody

Product Specifications

Background

This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6.

NCBI Gene ID

27000

Swiss Prot

Q99543

Accession Number

Q99543

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This DNAJC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-255 amino acids from the Central region of human DNAJC2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

72 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

DNAJC2

NCBI Official Name

DnaJ homolog subfamily C member 2

NCBI Organism

Homo sapiens

Background Reference 01

Hatzold, J., et al. PLoS Biol. (4), E84 (2008) :

Background Reference 02

Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

Background Reference 03

Otto, H., et al. Proc. Natl. Acad. Sci. U.S.A. 102 (29) :10064-10069 (2005)

Other Product Names

DnaJ homolog subfamily C member 2, M-phase phosphoprotein 11, Zuotin-related factor 1, DnaJ homolog subfamily C member 2, N-terminally processed, DNAJC2, MPHOSPH11, MPP11, ZRF1