CDC45L Antibody

Product Specifications

Background

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported.

NCBI Gene ID

8318

Swiss Prot

O75419

Accession Number

O75419

Host

Rabbit

Reactivity

Human

Immunogen

This CDC45L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-263 amino acids from the Central region of human CDC45L.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

66 kDa

Fragment

Rabbit Ig

Symbol

CDC45

NCBI Official Name

Cell division control protein 45 homolog

NCBI Organism

Homo sapiens

Background Reference 01

Chowdhury, A., et al. Mol. Cell. Biol. 30 (6) :1495-1507 (2010)

Background Reference 02

Im, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (37) :15628-15632 (2009)

Background Reference 03

Ballabeni, A., et al. J. Biol. Chem. 284 (5) :3028-3036 (2009)

Background Reference 04

Enjuanes, A., et al. Cancer Res. 68 (24) :10178-10186 (2008)

Other Product Names

Cell division control protein 45 homolog, PORC-PI-1, CDC45, CDC45L, CDC45L2

Tested Applications

WB, IHC-P, Flow

Physical Properties

Liquid

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