MAP4K3 Antibody

Product Specifications

Background

MAP4K3 encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1) . This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) .

NCBI Gene ID

8491

Swiss Prot

Q8IVH8

Accession Number

Q8IVH8

Host

Rabbit

Reactivity

Human

Immunogen

This MAP4K3 antibody is generated from rabbits immunized with a recombinant protein of human MAP4K3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

101 kDa

Fragment

Rabbit Ig

Symbol

MAP4K3

NCBI Official Name

Mitogen-activated protein kinase kinase kinase kinase 3

NCBI Organism

Homo sapiens

Background Reference 01

Yan, L., et al. Mol. Cell 37 (5) :633-642 (2010)

Background Reference 02

Ichikawa, S., et al. J. Bone Miner. Res. (2010) In press :

Background Reference 03

Lam, D., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (29) :11978-11983 (2009)

Background Reference 04

Wu, C., et al. Proteomics 7 (11) :1775-1785 (2007)

Other Product Names

Mitogen-activated protein kinase kinase kinase kinase 3, Germinal center kinase-related protein kinase, GLK, MAPK/ERK kinase kinase kinase 3, MEK kinase kinase 3, MEKKK 3, MAP4K3, RAB8IPL1