CACNA2D3 Antibody

Product Specifications

Background

CACNA2D3 is a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits.

NCBI Gene ID

55799

Swiss Prot

Q8IZS8

Accession Number

Q8IZS8

Host

Rabbit

Reactivity

Human

Immunogen

This CACNA2D3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1026-1053 amino acids from the C-terminal region of human CACNA2D3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

123 kDa

Fragment

Rabbit Ig

Symbol

CACNA2D3

NCBI Official Name

Voltage-dependent calcium channel subunit alpha-2/delta-3

NCBI Organism

Homo sapiens

Background Reference 01

Trynka, G., et al. Gut 58 (8) :1078-1083 (2009)

Background Reference 02

Wanajo, A., et al. Gastroenterology 135 (2) :580-590 (2008)

Background Reference 03

Uhl, G.R., et al. Arch. Gen. Psychiatry 65 (6) :683-693 (2008)

Background Reference 04

Abo-Dalo, B., et al. Am. J. Med. Genet.143A (22), 2668-2674 (2007)

Other Product Names

Voltage-dependent calcium channel subunit alpha-2/delta-3, Voltage-gated calcium channel subunit alpha-2/delta-3, Voltage-dependent calcium channel subunit alpha-2-3, Voltage-dependent calcium channel subunit delta-3, CACNA2D3