TLE1 Antibody

Product Specifications

Background

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

NCBI Gene ID

7088

Swiss Prot

Q04724

Accession Number

Q04724

Host

Rabbit

Reactivity

Human

Immunogen

This TLE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-228 amino acids from the Central region of human TLE1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

83 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TLE1

NCBI Official Name

Transducin-like enhancer protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Ali, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (9) :4165-4169 (2010)

Background Reference 02

Jagdis, A., et al. Am. J. Surg. Pathol. 33 (12) :1743-1751 (2009)

Background Reference 03

Kosemehmetoglu, K., et al. Mod. Pathol. 22 (7) :872-878 (2009)

Other Product Names

Transducin-like enhancer protein 1, E (Sp1) homolog, Enhancer of split groucho-like protein 1, ESG1, TLE1

Tested Applications

Protein ID

29840816

Physical Properties

Liquid

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