MCM2 Antibody

Product Specifications

Background

MCM2 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.

NCBI Gene ID

4171

Swiss Prot

P49736

Accession Number

P49736

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This MCM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 649-677 amino acids from the C-terminal region of human MCM2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Xenopus

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

102 kDa

Fragment

Rabbit Ig

Symbol

MCM2

NCBI Official Name

DNA replication licensing factor MCM2

NCBI Organism

Homo sapiens

Background Reference 01

Saade, E., et al. Proteomics 9 (21) :4934-4943 (2009)

Background Reference 02

Xu, X., et al. EMBO J. 28 (19) :3005-3014 (2009)

Background Reference 03

Liaw, K., et al. J. Cutan. Pathol. 36 (10) :1121-1122 (2009)

Background Reference 04

Im, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (37) :15628-15632 (2009)

Other Product Names

DNA replication licensing factor MCM2, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28, MCM2, BM28, CCNL1, CDCL1, KIAA0030

Tested Applications

WB, IHC-P

Protein ID

41019490

Physical Properties

Liquid

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