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DIO2 Antibody

Product Specifications

Background

DIO2 belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3) .

NCBI Gene ID

1734

Swiss Prot

Q92813

Accession Number

Q92813

Host

Rabbit

Reactivity

Human

Immunogen

This DIO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-191 amino acids from the Central region of human DIO2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Pig

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

31 kDa

Fragment

Rabbit Ig

Symbol

DIO2

NCBI Official Name

Type II iodothyronine deiodinase

NCBI Organism

Homo sapiens

Background Reference 01

He, B., et.al., Prog. Neuropsychopharmacol. Biol. Psychiatry 33 (6), 986-990 (2009)

Background Reference 02

Heemstra, K.A., et.al., J. Clin. Endocrinol. Metab. 94 (6), 2144-2150 (2009)

Other Product Names

Type II iodothyronine deiodinase, 5DII, DIOII, Type 2 DI, Type-II 5'-deiodinase, DIO2, ITDI2, TXDI2

Tested Applications

WB, IHC-P, Flow

Protein ID

172045839

Physical Properties

Liquid

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