MAP2K2 Antibody

Product Specifications

Background

MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.

NCBI Gene ID

5605

Swiss Prot

P36507

Accession Number

P36507

Host

Rabbit

Reactivity

Human

Immunogen

This MAP2K2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 372-400 amino acids from human MAP2K2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

44 kDa

Fragment

Rabbit Ig

Symbol

MAP2K2

NCBI Official Name

Dual specificity mitogen-activated protein kinase kinase 2

NCBI Organism

Homo sapiens

Background Reference 01

Burroughs, K.D., et al., Mol. Cancer Res. 1 (4) :312-322 (2003) .

Background Reference 02

Tran, H., et al., Mol. Cell. Biol. 23 (20) :7177-7188 (2003) .

Background Reference 03

Li, S.P., et al., Cancer Res. 63 (13) :3473-3477 (2003) .

Background Reference 04

Li, Y., et al., J. Biol. Chem. 278 (16) :13663-13671 (2003) .

Other Product Names

Dual specificity mitogen-activated protein kinase kinase 2, MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2, MEK 2, MAP2K2, MEK2, MKK2, PRKMK2