TEC Antibody
Product Specifications
Background
TEC belongs to the TEC subfamily of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. TEC family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. TEC kinase is an integral component of T cell signaling and has a distinct role in T cell activation. TEC may be associated with myelodysplastic syndrome.
NCBI Gene ID
7006
Swiss Prot
P42680
Accession Number
P42680
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This TEC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-205 amino acids from the Central region of human TEC.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
74 kDa
Fragment
Rabbit Ig
Symbol
TEC
NCBI Official Name
Tyrosine-protein kinase Tec
NCBI Organism
Homo sapiens
Background Reference 01
Nore, B.F., et al., Biochim. Biophys. Acta 1645 (2) :123-132 (2003) .
Background Reference 02
Maltais, A., et al., Cancer Lett. 183 (1) :87-94 (2002) .
Background Reference 03
Lachance, G., et al., J. Biol. Chem. 277 (24) :21537-21541 (2002) .
Background Reference 04
Yang, W.C., et al., Immunity 12 (4) :373-382 (2000) .
Other Product Names
Tyrosine-protein kinase Tec, TEC, PSCTK4
Tested Applications
WB, IHC-P, IF
Protein ID
158518392
Physical Properties
Liquid
Curated Selection
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