ABL1 Antibody

Product Specifications

Background

ABL1 is a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.

NCBI Gene ID

Swiss Prot

P00519

Accession Number

P00519

Host

Rabbit

Reactivity

Human

Immunogen

This ABL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 741-769 amino acids from the Central region of human ABL1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

123 kDa

Fragment

Rabbit Ig

Symbol

ABL1

NCBI Official Name

Tyrosine-protein kinase ABL1

NCBI Organism

Homo sapiens

Background Reference 01

Donaldson, L.W., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (22) :14053-14058 (2002) .

Background Reference 02

Pisabarro, M.T., et al., J. Mol. Biol. 281 (3) :513-521 (1998) .

Background Reference 03

Nam, H.J., et al., Structure 4 (9) :1105-1114 (1996) .

Background Reference 04

Chissoe, S.L., et al., Genomics 27 (1) :67-82 (1995) .

Other Product Names

Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, ABL1, ABL, JTK7