CLOCK Antibody

Product Specifications

Background

CLOCK belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within this protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.

NCBI Gene ID

9575

Swiss Prot

O15516

Accession Number

O15516

Host

Rabbit

Reactivity

Human

Immunogen

This CLOCK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-249 amino acids from the Central region of human CLOCK.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Neuroscience, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

95 kDa

Fragment

Rabbit Ig

Symbol

CLOCK

NCBI Official Name

Circadian locomoter output cycles protein kaput

NCBI Organism

Homo sapiens

Background Reference 01

Sookoian, S., Am. J. Clin. Nutr. 87 (6), 1606-1615 (2008)

Background Reference 02

Nakashima, A., Mol. Cell. Biol. 28 (12), 4080-4092 (2008)

Background Reference 03

Marino, J.L., Epidemiology 19 (3), 477-484 (2008)

Other Product Names

Circadian locomoter output cycles protein kaput, hCLOCK, Class E basic helix-loop-helix protein 8, bHLHe8, CLOCK, BHLHE8, KIAA0334

Tested Applications

WB, IHC-P

Physical Properties

Liquid

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