CDK2 Antibody

Product Specifications

Background

CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B) . Its activity is also regulated by its protein phosphorylation.

NCBI Gene ID

1017

Swiss Prot

P24941

Accession Number

P24941

Host

Rabbit

Reactivity

Human

Immunogen

This CDK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-260 amino acids from the C-terminal region of human CDK2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Hamster, Mouse, Rat, Xenopus

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

34 kDa

Fragment

Rabbit Ig

Symbol

CDK2

NCBI Official Name

Cyclin-dependent kinase 2

NCBI Organism

Homo sapiens

Background Reference 01

Moshinsky, D.J., et al., Biochem. Biophys. Res. Commun. 310 (3) :1026-1031 (2003) .

Background Reference 02

Chow, J.P., et al., J. Biol. Chem. 278 (42) :40815-40828 (2003) .

Background Reference 03

O'Nions, J., et al., Oncogene 22 (46) :7181-7191 (2003) .

Background Reference 04

Yun, J., et al., J. Biol. Chem. 278 (38) :36966-36972 (2003) .

Other Product Names

Cyclin-dependent kinase 2, Cell division protein kinase 2, p33 protein kinase, CDK2, CDKN2

Tested Applications

WB, IHC-P, Flow

Protein ID

116051

Physical Properties

Liquid

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