MAPK1 Antibody

Product Specifications

Background

ERK2 is a member of the MAP kinase subfamily of Ser/Thr protein kinases. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets.

NCBI Gene ID

5594

Swiss Prot

P28482

Accession Number

P28482

Host

Rabbit

Reactivity

Human

Immunogen

This MAPK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 254-285 amino acids from the C-terminal region of human MAPK1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Immunology, Obesity, Neuroscience, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat, Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

41 kDa

Fragment

Rabbit Ig

Symbol

MAPK1

NCBI Official Name

Mitogen-activated protein kinase 1

NCBI Organism

Homo sapiens

Background Reference 01

Grey, A., et al., Endocrinology 144 (11) :4886-4893 (2003) .

Background Reference 02

Sawafuji, K., et al., Am. J. Hematol. 72 (1) :67-69 (2003) .

Background Reference 03

Liao, Y., et al., Mol. Cell. Biol. 23 (19) :6836-6848 (2003) .

Background Reference 04

Garcia-Lora, A., et al., Cancer Immunol. Immunother. 52 (1) :59-64 (2003) .

Other Product Names

Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, MAPK1, ERK2, PRKM1, PRKM2