GIT1-S388 Antibody

GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes (from SwissProt) .

This GIT1-S388 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-395 amino acids from the Central region of human GIT1-S388.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Kawachi, H., et al. Proc. Natl. Acad. Sci. U.S.A. 98 (12) :6593-6598 (2001) Zhao, Z.S., et al. Mol. Cell. Biol. 20 (17) :6354-6363 (2000) Premont, R.T., et al. J. Biol. Chem. 275 (29) :22373-22380 (2000) Premont, R.T., et al. Proc. Natl. Acad. Sci. U.S.A. 95 (24) :14082-14087 (1998)

ARF GTPase-activating protein GIT1, ARF GAP GIT1, Cool-associated and tyrosine-phosphorylated protein 1, CAT-1, CAT1, G protein-coupled receptor kinase-interactor 1, GRK-interacting protein 1, GIT1