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MGMT Antibody

Product Specifications

Background

MGMT is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. This protein repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the protein is irreversibly inactivated.

NCBI Gene ID

4255

Swiss Prot

P16455

Accession Number

P16455

Host

Rabbit

Reactivity

Human

Immunogen

This MGMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-182 amino acids from the C-terminal region of human MGMT.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

22 kDa

Fragment

Rabbit Ig

Symbol

MGMT

NCBI Official Name

Methylated-DNA--protein-cysteine methyltransferase

NCBI Organism

Homo sapiens

Background Reference 01

Kim, J.I., Suh, J.T. Hum. Pathol. 40 (7), 934-941 (2009)

Background Reference 02

Chen, S.P., Chiu, S.C. Genet Test Mol Biomarkers 13 (1), 67-71 (2009)

Background Reference 03

Slupphaug, G., Lettrem, I. Carcinogenesis 13 (10), 1769-1773 (1992)

Background Reference 04

Lee, S.M., Crowther, D. Br. J. Cancer 66 (2), 331-336 (1992)

Other Product Names

Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, MGMT, O-6-methylguanine-DNA-alkyltransferase, MGMT

Tested Applications

WB, IHC-P, Flow

Protein ID

127069

Physical Properties

Liquid

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