MAPK11 Antibody

Product Specifications

Background

MAPK11 is a Ser/Thr kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. It preferentially phosphorylates transcription factor ATF2. This protein is activated by phosphorylation on threonine and tyrosine by MKK6, and is inhibited by pyridinyl-imidazole related compounds. Highest expression levels are in the brain and heart, with additional expression in the placenta, lung, liver, skeletal muscle, kidney and pancreas.

NCBI Gene ID

5600

Swiss Prot

Q15759

Accession Number

Q15759

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This MAPK11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 334-366 amino acids from the center region of human MAPK11.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

41 kDa

Fragment

Rabbit Ig

Symbol

MAPK11

NCBI Official Name

Mitogen-activated protein kinase 11

NCBI Organism

Homo sapiens

Background Reference 01

Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) .

Background Reference 02

Dunham, I., et al., Nature 402 (6761) :489-495 (1999) .

Background Reference 03

Enslen, H., et al., J. Biol. Chem. 273 (3) :1741-1748 (1998) .

Background Reference 04

Kumar, S., et al., Biochem. Biophys. Res. Commun. 235 (3) :533-538 (1997) .

Other Product Names

Mitogen-activated protein kinase 11, MAP kinase 11, MAPK 11, Mitogen-activated protein kinase p38 beta, MAP kinase p38 beta, p38b, Stress-activated protein kinase 2b, SAPK2b, p38-2, MAPK11, PRKM11, SAPK2, SAPK2B