MELK Antibody

Product Specifications

Background

MELK contains 1 protein kinase domain that belongs to the Ser/Thr protein kinase family. It phosphorylates ZNF622 and may contribute to its redirection to the nucleus. MELK may also be involved in the inhibition of spliceosome assembly during mitosis.

NCBI Gene ID

9833

Swiss Prot

Q14680

Accession Number

Q14680

Host

Rabbit

Reactivity

Human

Immunogen

This MELK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 amino acids from the Central region of human MELK.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Cell Cycle, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

75 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MELK

NCBI Official Name

Maternal embryonic leucine zipper kinase

NCBI Organism

Homo sapiens

Background Reference 01

Davezac, N., et al., Oncogene 21 (50) :7630-7641 (2002) .

Background Reference 02

Heyer, B.S., et al., Mol. Reprod. Dev. 47 (2) :148-156 (1997) .

Other Product Names

Maternal embryonic leucine zipper kinase, hMELK, Protein kinase Eg3, pEg3 kinase, Protein kinase PK38, hPK38, Tyrosine-protein kinase MELK, MELK, KIAA0175