ERN2 Antibody
Product Specifications
Background
ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.
NCBI Gene ID
10595
Swiss Prot
Q76MJ5
Accession Number
Q76MJ5
Host
Rabbit
Reactivity
Human
Immunogen
This ERN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-72 amino acids from the N-terminal region of human ERN2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
102 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ERN2
NCBI Official Name
Serine/threonine-protein kinase/endoribonuclease IRE2
NCBI Organism
Homo sapiens
Background Reference 01
Iwawaki, T., et al., Nat. Cell Biol. 3 (2) :158-164 (2001) .
Background Reference 02
Niwa, M., et al., Cell 99 (7) :691-702 (1999) .
Background Reference 03
Wang, X.Z., et al., EMBO J. 17 (19) :5708-5717 (1998) .
Other Product Names
HGNC:16942
Tested Applications
WB
Protein ID
327478597
Physical Properties
Liquid
Curated Selection
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