PDK2 Antibody

Product Specifications

Background

PDK2 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.

NCBI Gene ID

5164

Swiss Prot

Q15119

Accession Number

Q15119

Host

Rabbit

Reactivity

Human

Immunogen

This PDK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 378-407 amino acids from the C-terminal region of human PDK2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat, Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

46 kDa

Fragment

Rabbit Ig

Symbol

PDK2

NCBI Official Name

[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 2, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Hiromasa, Y., et al., J. Biol. Chem. 278 (36) :33681-33693 (2003) . Baker, J.C., et al., J. Biol. Chem. 275 (21) :15773-15781 (2000) . Gudi, R., et al., J. Biol. Chem. 270 (48) :28989-28994 (1995) . Sun, W. et al. Clin Cancer Res. January 15; 15 (2) : 476?84 (2009) .

Other Product Names

[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 2, mitochondrial, Pyruvate dehydrogenase kinase isoform 2, PDH kinase 2, PDKII, PDK2, PDHK2