ARGBP2 Antibody

Product Specifications

Background

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. ARGBP2 is the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton.

NCBI Gene ID

8470

Swiss Prot

O94875

Accession Number

O94875

Host

Rabbit

Reactivity

Human

Immunogen

This ARGBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-204 amino acids from the N-terminal region of human ARGBP2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Pig, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

124 kDa

Fragment

Rabbit Ig

Symbol

SORBS2

NCBI Official Name

Sorbin and SH3 domain-containing protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Yuan, Z.Q., et.al., J. Biol. Chem. 280 (22), 21483-21490 (2005)

Background Reference 02

Olsen, J.V., et.al., Cell 127 (3), 635-648 (2006)

Background Reference 03

Taieb, D., et.al., Cancer Res. 68 (12), 4588-4596 (2008)

Other Product Names

Sorbin and SH3 domain-containing protein 2, Arg/Abl-interacting protein 2, ArgBP2, Sorbin, SORBS2, ARGBP2, KIAA0777

Tested Applications

WB, IHC-P, IF, Flow

Physical Properties

Liquid

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