GNAS Antibody

Product Specifications

Background

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G (s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms.

NCBI Gene ID

2778

Swiss Prot

Q5JWF2

Accession Number

Q5JWF2

Host

Rabbit

Reactivity

Human

Immunogen

This GNAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 640-667 amino acids from the Central region of human GNAS.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

111 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:4000

Symbol

GNAS

NCBI Official Name

Guanine nucleotide-binding protein G (s) subunit alpha isoforms XLas

NCBI Organism

Homo sapiens

Background Reference 01

Liu, C., et.al., Eur Arch Otorhinolaryngol (2009)

Background Reference 02

Nishihara, E., et.al., Endocr. J. 56 (6), 791-798 (2009)

Other Product Names

Guanine nucleotide-binding protein G (s) subunit alpha isoforms XLas, Adenylate cyclase-stimulating G alpha protein, Extra large alphas protein, XLalphas, GNAS, GNAS1 {ECO:0000303|PubMed:9707596}