Cdc25A Antibody
Product Specifications
Background
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated.
NCBI Gene ID
993
Swiss Prot
P30304
Accession Number
P30304
Host
Rabbit
Reactivity
Human
Immunogen
This Cdc25A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-300 amino acids from the Central region of human Cdc25A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
59 kDa
Fragment
Rabbit Ig
Symbol
CDC25A
NCBI Official Name
M-phase inducer phosphatase 1
NCBI Organism
Homo sapiens
Background Reference 01
Ito, Y., et al., Int. J. Mol. Med. 13 (3) :431-435 (2004) .
Background Reference 02
Nemoto, K., et al., Prostate 58 (1) :95-102 (2004) .
Background Reference 03
Goloudina, A., et al., Cell Cycle 2 (5) :473-478 (2003) .
Background Reference 04
Chen, M.S., et al., Mol. Cell. Biol. 23 (21) :7488-7497 (2003) .
Other Product Names
M-phase inducer phosphatase 1, Dual specificity phosphatase Cdc25A, CDC25A
Tested Applications
WB, IHC-P
Protein ID
50403734
Physical Properties
Liquid
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