RB1 Antibody

Product Specifications

Background

The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in many types of cancer.[1] One highly studied function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins.[2][3] Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomaviruses, bind and inactivate pRb, this can lead to cancer. Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral.

NCBI Gene ID

5925

Swiss Prot

P06400

Accession Number

P06400

Host

Rabbit

Reactivity

Human

Immunogen

This RB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-615 amino acids from human RB1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

106 kDa

Fragment

Rabbit Ig

Symbol

RB1

NCBI Official Name

Retinoblastoma-associated protein

NCBI Organism

Homo sapiens

Background Reference 01

Dasgupta, P., et al., Mol. Cell. Biol. 24 (21) :9527-9541 (2004) .

Background Reference 02

Cui, X., et al., Hum. Pathol. 35 (10) :1189-1195 (2004) .

Background Reference 03

Borah, S., et al., J. Virol. 78 (19) :10336-10347 (2004) .

Background Reference 04

Dasgupta, P., et al., J. Biol. Chem. 279 (37) :38762-38769 (2004) .

Other Product Names

Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110, RB1

Tested Applications

WB, IHC-P, IF

Protein ID

132164

Physical Properties

Liquid

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

EF001579 96 Tests

Human PAX6 ELISA KIT

Ask

View Details

42365141 1x 10^6 Cells / 1.0 mL

RPS27AP4 CRISPR Knock Out 293T Cell Line (Human)

Ask

View Details

A32047-100UG 100 µg

PRMT3 Antibody, HRP conjugated

Ask

View Details

PVT11499 2 µg

pENTR223-UBE2U Plasmid

Ask

View Details

128994 100 µg

LAMP2 (Lysosome-associated Membrane Glycoprotein 2, LAMP-2, Lysosome-associated Membrane Protein 2, CD107 Antigen-like Family Member B, CD107b)

Ask

View Details