ST5 Antibody

Product Specifications

Background

ST5 was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells.

NCBI Gene ID

6764

Swiss Prot

P78524

Accession Number

P78524

Host

Rabbit

Reactivity

Human

Immunogen

This ST5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1106-1137 amino acids from the C-terminal region of human ST5.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

126 kDa

Fragment

Rabbit Ig

Symbol

ST5

NCBI Official Name

Suppression of tumorigenicity 5 protein

NCBI Organism

Homo sapiens

Background Reference 01

Majidi, M., et al., J. Biol. Chem. 275 (9) :6560-6565 (2000) .

Background Reference 02

Hubbs, A.E., et al., Oncogene 18 (15) :2519-2525 (1999) .

Background Reference 03

Majidi, M., et al., J. Biol. Chem. 273 (26) :16608-16614 (1998) .

Background Reference 04

Lichy, J.H., et al., Nucleic Acids Res. 24 (23) :4700-4708 (1996) .

Other Product Names

Suppression of tumorigenicity 5 protein, DENN domain-containing protein 2B, HeLa tumor suppression 1, ST5, DENND2B, HTS1

Tested Applications

WB, Flow

Protein ID

317373507

Physical Properties

Liquid

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