MAGEA3 Antibody

MAGEA3 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80% sequence identity between each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are expressed at a high level in a number of tumors of various histologic types, and are silent in normal tissues with the exception of testis and placenta. The MAGEA genes are clustered on chromosome Xq28. They may be implicated in some hereditary disorders, such as dyskeratosis congenita.

This MAGEA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-314 amino acids from the C-terminal region of human MAGEA3.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Guo, J., et al., Exp. Mol. Pathol. 74 (2) :140-147 (2003) . Consogno, G., et al., Blood 101 (3) :1038-1044 (2003) . Rogner, U.C., et al., Genomics 29 (3) :725-731 (1995) . Gaugler, B., et al., J. Exp. Med. 179 (3) :921-930 (1994) . van der Bruggen, P., et al., Science 254 (5038) :1643-1647 (1991) .