GREMLIN Antibody

GREMLIN is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth.

This GREMLIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 amino acids from the C-terminal region of mouse GREMLIN.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Chen, B., et al., J. Immunol. 173 (10) :5914-5917 (2004) . Chen, B., et al., Biochem. Biophys. Res. Commun. 295 (5) :1135-1141 (2002) . McMahon, R., et al., J. Biol. Chem. 275 (14) :9901-9904 (2000) . Murphy, M., et al., J. Biol. Chem. 274 (9) :5830-5834 (1999) . Hsu, D.R., et al., Mol. Cell 1 (5) :673-683 (1998) .