ABCB7 Antibody

Product Specifications

Background

The membrane-associated protein ABCB7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.

NCBI Gene ID

Swiss Prot

O75027

Accession Number

O75027

Host

Rabbit

Reactivity

Human

Immunogen

This ABCB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 718-746 amino acids from the C-terminal region of human ABCB7.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

83 kDa

Fragment

Rabbit Ig

Symbol

ABCB7

NCBI Official Name

ATP-binding cassette sub-family B member 7, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Allikmets, R., et al., Hum. Mol. Genet. 8 (5) :743-749 (1999) .

Background Reference 02

Csere, P., et al., FEBS Lett. 441 (2) :266-270 (1998) .

Background Reference 03

Mao, M., et al., Proc. Natl. Acad. Sci. U.S.A. 95 (14) :8175-8180 (1998) .

Background Reference 04

Shimada, Y., et al., J. Hum. Genet. 43 (2) :115-122 (1998) .

Other Product Names

ATP-binding cassette sub-family B member 7, mitochondrial, ATP-binding cassette transporter 7, ABC transporter 7 protein, ABCB7, ABC7

Tested Applications

WB, IHC-P

Physical Properties

Liquid

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