MAP3K11 Antibody

Product Specifications

Background

MAP3K11 is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.

NCBI Gene ID

4296

Swiss Prot

Q16584

Accession Number

Q16584

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This MAP3K11 antibody is generated from rabbits immunized with MAP3K11 recombinant protein.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

93 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MAP3K11

NCBI Official Name

Mitogen-activated protein kinase kinase kinase 11

NCBI Organism

Homo sapiens

Background Reference 01

Rangasamy, V., et al. Cancer Res. 70 (4) :1731-1740 (2010)

Background Reference 02

Velho, S., et al. Hum. Mol. Genet. 19 (4) :697-706 (2010)

Background Reference 03

Cole, E.T., et al. Biochim. Biophys. Acta 1793 (12) :1811-1818 (2009)

Other Product Names

HGNC:6850

Tested Applications

Protein ID

71153819

Physical Properties

Liquid

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