FOLR2 Antibody
Product Specifications
Background
FOLR2 is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients.
NCBI Gene ID
2350
Swiss Prot
P14207
Accession Number
P14207
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This FOLR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human FOLR2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=61-763
Calculated Molecular Weight
29 kDa
Fragment
Rabbit Ig
Symbol
FOLR2
NCBI Official Name
Folate receptor beta
NCBI Organism
Homo sapiens
Background Reference 01
Puig-Kroger, A., et al. Cancer Res. 69 (24) :9395-9403 (2009) Boyles, A.L., et al. Genet. Epidemiol. 33 (3) :247-255 (2009) Franke, B., et al. Birth Defects Res. PartClin. Mol. Teratol. 85 (3) :216-226 (2009)
Other Product Names
Folate receptor beta, FR-beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein, FBP, FOLR2
Tested Applications
WB, IHC-P, Flow
Protein ID
116241366
Physical Properties
Liquid
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