PIGM Antibody

Product Specifications

Background

PIGM encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) -anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. PIGM encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum.

NCBI Gene ID

93183

Swiss Prot

Q9H3S5

Accession Number

Q9H3S5

Host

Rabbit

Reactivity

Human

Immunogen

This PIGM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 394-423 amino acids from the C-terminal region of human PIGM.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

49 kDa

Fragment

Rabbit Ig

Symbol

PIGM

NCBI Official Name

GPI mannosyltransferase 1

NCBI Organism

Homo sapiens

Background Reference 01

Almeida, A.M., et al. Nat. Med. 12 (7) :846-851 (2006) Maeda, Y., et al. EMBO J. 20 (1-2), 250-261 (2001) Kinoshita, T., et al. Curr Opin Chem Biol 4 (6) :632-638 (2000)