ABL Antibody

Product Specifications

Background

ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length. The peptide used to generate this antibody is 100% conserved between ABL2 and ABL1.

NCBI Gene ID

Swiss Prot

P00519

Accession Number

P00519

Host

Rabbit

Reactivity

Human

Immunogen

This ABL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y251 of human ABL.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

123 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ABL1

NCBI Official Name

Tyrosine-protein kinase ABL1

NCBI Organism

Homo sapiens

Background Reference 01

Cao, C., et al., Biochemistry 42 (35) :10348-10353 (2003) .

Background Reference 02

Cao, C., et al., J. Biol. Chem. 278 (32) :29667-29675 (2003) .

Background Reference 03

Kruh, G.D., et al., Proc. Natl. Acad. Sci. U.S.A. 87 (15) :5802-5806 (1990) .

Background Reference 04

Kruh, G.D., et al., Science 234 (4783) :1545-1548 (1986) .

Other Product Names

Abelson tyrosine-protein kinase 2, Abelson murine leukemia viral oncogene homolog 2, Abelson-related gene protein, Tyrosine-protein kinase ARG, ABL2, ABLL, ARG