ENPP2 Antibody

Product Specifications

Background

ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This protein stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. This protein is secreted and further processed to make the biologically active form.

NCBI Gene ID

5168

Swiss Prot

Q13822

Accession Number

Q13822

Host

Rabbit

Reactivity

Human

Immunogen

This ENPP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-430 amino acids from the Central region of human ENPP2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Neuroscience, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

99 kDa

Fragment

Rabbit Ig

Symbol

ENPP2

NCBI Official Name

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

NCBI Organism

Homo sapiens

Background Reference 01

Kawagoe H., Soma O., Goji J., Nishimura N., Narita M., Genomics 30:380-384 (1995)

Background Reference 02

Nam S.W., Clair T., Kim Y.S., McMarlin A., Cancer Res. 61:6938-6944 (2001)

Background Reference 03

The MGC Project Team Genome Res. 14:2121-2127 (2004)

Other Product Names

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, E-NPP 2, Autotaxin, Extracellular lysophospholipase D, LysoPLD, ENPP2, ATX, PDNP2

Tested Applications

WB, IHC-P, Flow

Protein ID

290457674

Physical Properties

Liquid

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