SSB Antibody
Product Specifications
Background
SSB is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III -transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. This protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and systemic lupus erythematosus.
NCBI Gene ID
6741
Swiss Prot
P05455
Accession Number
P05455
Host
Rabbit
Reactivity
Human
Immunogen
This SSB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-397 amino acids from the C-terminal region of human SSB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rb
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
47 kDa
Fragment
Rabbit Ig
Symbol
SSB
NCBI Official Name
Lupus La protein
NCBI Organism
Homo sapiens
Background Reference 01
Bitko, V., J. Virol. 82 (16), 7977-7987 (2008)
Background Reference 02
Kotik-Kogan, O., Structure 16 (6), 852-862 (2008)
Background Reference 03
Biswas, D., Clin. Rheumatol. 27 (6), 717-722 (2008)
Other Product Names
Lupus La protein, La autoantigen, La ribonucleoprotein, Sjoegren syndrome type B antigen, SS-B, SSB
Tested Applications
WB, IHC-P
Protein ID
125985
Physical Properties
Liquid
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