Prohibitin Antibody

Product Specifications

Background

Prohibitin is an evolutionarily conserved protein that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region.

NCBI Gene ID

5245

Swiss Prot

P35232

Accession Number

P35232

Host

Rabbit

Reactivity

Human

Immunogen

This Prohibitin (PHB1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-121 amino acids from the N-terminal region of human Prohibitin (PHB1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Obesity

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Chicken

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

30 kDa

Fragment

Rabbit Ig

Symbol

PHB

NCBI Official Name

Prohibitin

NCBI Organism

Homo sapiens

Background Reference 01

Gregory-Bass, R.C., Int. J. Cancer 122 (9), 1923-1930 (2008) Ross, J.A., J. Biol. Chem. 283 (8), 4699-4713 (2008) White, J.J., Genomics 11 (1), 228-230 (1991)