ICMT Antibody
Product Specifications
Background
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing results in two transcript variants encoding different isoforms.
NCBI Gene ID
23463
Swiss Prot
O60725
Accession Number
O60725
Host
Rabbit
Reactivity
Human
Immunogen
This ICMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-284 amino acids from the C-terminal region of human ICMT.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
32 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ICMT
NCBI Official Name
Protein-S-isoprenylcysteine O-methyltransferase
NCBI Organism
Homo sapiens
Background Reference 01
Bergo, M.O., et al., J. Clin. Invest. 113 (4) :539-550 (2004) .
Background Reference 02
Ahmad, M., et al., Arterioscler. Thromb. Vasc. Biol. 22 (5) :759-764 (2002) .
Background Reference 03
Van Dessel, G.A., et al., Int. J. Biochem. Cell Biol. 34 (5) :477-486 (2002) .
Background Reference 04
Dai, Q., et al., J. Biol. Chem. 273 (24) :15030-15034 (1998) .
Other Product Names
Protein-S-isoprenylcysteine O-methyltransferase, Isoprenylcysteine carboxylmethyltransferase, Prenylated protein carboxyl methyltransferase, PPMT, Prenylcysteine carboxyl methyltransferase, pcCMT, ICMT, PCCMT
Tested Applications
WB
Physical Properties
Liquid
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