W-54011
Product Specifications
UNSPSC Description
W-54011 is a potent and orally active non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils with a Ki value of 2.2 nM. W-54011 also inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophils with IC50s of 3.1 nM, 2.7 nM, and 1.6 nM, respectively[1].
Target Antigen
Complement System; Reactive Oxygen Species
Type
Reference compound
Related Pathways
Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/W-54011.html
Solubility
DMSO : ≥ 28 mg/mL
Smiles
O=C(C1CCCC2=C1C=C(OC)C=C2)N(CC3=CC=C(N(C)C)C=C3)C4=CC=C(C(C)C)C=C4.[H]Cl
Molecular Weight
493.08
References & Citations
[1]Sumichika H, et al. Identification of a potent and orally active non-peptide C5a receptor antagonist. J Biol Chem. 2002 Dec 20;277(51):49403-49407.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16992A/W-54011-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16992A/W-54011-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
405098-33-1
Available Sizes
Curated Selection
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