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BCDIN3D Antibody

Product Specifications

Background

O-methyltransferase that specifically dimethylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre- miRNAs.

NCBI Gene ID

144233

Swiss Prot

Q7Z5W3

Accession Number

Q7Z5W3

Host

Rabbit

Reactivity

Human

Immunogen

This BCDIN3D antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 243-276 amino acids from human BCDIN3D.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

33 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000-2000

Symbol

BCDIN3D

NCBI Official Name

Pre-miRNA 5'-monophosphate methyltransferase

NCBI Organism

Homo sapiens

Background Reference 01

Ota T., et al.Nat. Genet. 36:40-45 (2004) .

Background Reference 02

Mural R.J., et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

Background Reference 03

Xhemalce B., et al.Cell 151:278-288 (2012) .

Other Product Names

Pre-miRNA 5'-monophosphate methyltransferase, 2.1.1.-, BCDIN3 domain-containing protein, BCDIN3D

Tested Applications

WB

Protein ID

74738762

Physical Properties

Liquid

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