PSEN2 Antibody
Product Specifications
Background
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) . Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
NCBI Gene ID
5664
Swiss Prot
P49810
Accession Number
P49810
Host
Rabbit
Reactivity
Human
Immunogen
This PSEN2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-65 amino acids from the N-terminal region of human PSEN2 (Presenilin-2 NTF subunit) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
50 kDa
Fragment
Rabbit Ig
Symbol
PSEN2
NCBI Official Name
Presenilin-2
NCBI Organism
Homo sapiens
Background Reference 01
Levy-Lahad E., et al.Science 269:973-977 (1995) .
Background Reference 02
Rogaev E.I., et al.Nature 376:775-778 (1995) .
Background Reference 03
Li J., et al.Proc. Natl. Acad. Sci. U.S.A. 92:12180-12184 (1995) .
Background Reference 04
Levy-Lahad E., et al.Genomics 34:198-204 (1996) .
Other Product Names
Presenilin-2, PS-2, 3423-, AD3LP, AD5, E5-1, STM-2, Presenilin-2 NTF subunit, Presenilin-2 CTF subunit, PSEN2, AD4, PS2, PSNL2, STM2
Tested Applications
WB, Flow
Protein ID
1709858
Physical Properties
Liquid
Curated Selection
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