Mouse Txnip Antibody

Product Specifications

Background

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.

NCBI Gene ID

56338

Swiss Prot

Q8BG60

Accession Number

Q8BG60

Host

Rabbit

Reactivity

Mouse

Immunogen

This Mouse Txnip antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-145 amino acids from the Central region of mouse Txnip.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

44 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Txnip

NCBI Official Name

Thioredoxin-interacting protein

NCBI Organism

Mus musculus

Background Reference 01

Kwon, H.J., et al. Toxicol. Appl. Pharmacol. 248 (3) :277-284 (2010)

Background Reference 02

Kwon, H.J., et al. J. Immunol. 185 (7) :3980-3989 (2010)

Background Reference 03

Ren, Y., et al. FEBS Lett. 584 (15) :3480-3485 (2010)

Background Reference 04

Chutkow, W.A., et al. Diabetes 59 (6) :1424-1434 (2010)

Other Product Names

Thioredoxin-interacting protein, Vitamin D3 up-regulated protein 1, Txnip, Vdup1

Tested Applications

Physical Properties

Liquid

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