EIF4EBP2 Antibody

Product Specifications

Background

This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection.

NCBI Gene ID

1979

Swiss Prot

Q13542

Accession Number

Q13542

Host

Rabbit

Reactivity

Human

Immunogen

This EIF4EBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-115 amino acids from the C-terminal region of human EIF4EBP2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

13 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

EIF4EBP2

NCBI Official Name

Eukaryotic translation initiation factor 4E-binding protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Bailey, S.D., et al. Diabetes Care (2010) In press :

Background Reference 02

Bidinosti, M., et al. J. Biol. Chem. 285 (25) :19402-19408 (2010)

Background Reference 03

Johnatty, S.E., et al. PLoS Genet. (7), E1001016 (2010) :

Background Reference 04

Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

Other Product Names

Eukaryotic translation initiation factor 4E-binding protein 2, 4E-BP2, eIF4E-binding protein 2, EIF4EBP2

Tested Applications

Protein ID

34921510

Physical Properties

Liquid

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